The role of the microbiome in urology

The role of the microbiome in urology

by
With the arrival of novel excessive throughput-sequencing applied sciences we gained higher insights into the complicated and numerous interactions of the microbiome for well being and illness within the human physique. The idea of urinary sterility has lengthy been dismissed and now we try for deciphering numerous microbial signatures related to a illness.
A dysbalance of the microbiome seems to have a considerable affect on the pathogenesis of each malignant and benign situations. Novel preventive and therapeutic approaches and biomarker programs have been proposed for prostate most cancers, renal cell carcinoma and bladder most cancers based mostly on microbiome analyses.
The exclusion of a microbial origin was at all times a part of the prognosis of benign problems comparable to interstitial cystitis, urinary urge incontinence or power prostatitis/power pelvic ache syndrome. Now we’re sure that an imbalanced microbial profile performs an important position for the pathogenesis and illness administration of those difficult situations.

Frailty and aged in urology: implications for postoperative issues

The geriatric inhabitants is at a higher threat of postoperative issues than younger adults. This threat is related to the physiologic decline seen on this inhabitants referred to as frailty. In contrast to fitter sufferers, frail sufferers who endure operative remedy have a higher chance of growing postoperative issues and endure extended hospital stays. This circumstance is akin to the urological standing.
Due to this fact, tolerable measurement of frailty as a website of preoperative well being standing has been advised to determine vulnerability in aged sufferers. On this assessment, we’ll elaborate on the idea of frailty and study its significance with respect to surgical issues, specializing in the urological standing.

European Affiliation of Urology Urolithiasis Pointers: The place Are We Going?

Urolithiasis is a medical situation displaying rising tendencies, particularly amongst European and different developed nations. The European Affiliation of Urology (EAU), in shut collaboration with consultants within the discipline, publishes a yearly up to date medical guideline, so as to present working towards urologists round Europe and the remainder of the world a device for optimizing affected person care and decision-making.
The methodological strategy for growing this information is sort of rigorous and follows rigorous scientific requirements. The challenges {that a} urologist faces are rising; subsequently, throughout meticulous literature search, the EAU Urolithiasis Panel identifies gaps in information and conducts systematic evaluations, so as to present solutions or to suggest concepts for designing future analysis.
This manner, a brand new part was printed final 12 months, concerning prognosis and administration of bladder stones, with extra systematic evaluations on the best way. The purpose of this research is to investigate present construction and targets of the EAU Urolithiasis Panel, together with future ambitions and challenges.
PATIENT SUMMARY: Rising tendencies in kidney stone illness together with developments in know-how necessitate systematic group of knowledge for urologists so as to have the ability to observe diagnostic and therapeutic algorithms for optimizing affected person care. The position of the European Affiliation of Urology Urolithiasis Guideline Panel is to offer such a device by growth of urolithiasis tips on an annual foundation.

Present Antibiotic Resistance Tendencies of Uropathogens in Central Europe: Survey from a Tertiary Hospital Urology Division 2011-2019

Monitoring of pathogen resistance profiles is important to information empirical antibiotic remedy earlier than tradition and sensitivity outcomes change into out there. The purpose of this research was to explain present antibiotic resistance patterns of 5 most frequent causative uropathogens in a Division of Urology of a tertiary referral centre in Central Europe over a interval of 9 years. The Hospital Division of Scientific Microbiology database was used to extract knowledge on all constructive urine samples from inpatients within the Division of Urology between 2011 and 2019.
The role of the microbiome in urology
Numbers of prone and resistant isolates per 12 months had been calculated for 5 most frequent uropathogens: Escherichia coli, Enterococcus spp., Klebsiella spp., Pseudomonas aeruginosa, and Proteus spp. Antimicrobial brokers chosen for the survey included: ampicillin, amoxicillin/clavulanic acid, piperacillin/tazobactam; cefuroxime, cefotaxime, ceftazidime and cefepime; ciprofloxacin and ofloxacin; gentamicin and amikacin; ertapenem, meropenem and imipenem; trimethoprim-sulfamethoxazole (co-trimoxazole), nitrofurantoin, colistin, and vancomycin.
Excessive resistance charges of Gram-negative uropathogens had been demonstrated to most typical antimicrobials, with statistically important rising or reducing tendencies in some instances. No carbapenem-resistant Enterobacteriaceae had been remoted. Vancomycin-resistant Enterococcus spp. strains had been uncommon in our inhabitants.

Autonomous surgical procedure within the period of robotic urology: good friend or foe of the longer term surgeon?

Regardless of advances in robotic-assisted surgical procedure (RAS) prior to now twenty years, management of the robotic system presently stays beneath the command of a human surgeon. Traditionally, urology has pioneered new surgical strategies and applied sciences. Now, autonomous RAS is on the horizon and the primary knowledge from medical trials of autonomous RAS in urology are being printed.
Automation takes management away from the surgeon however guarantees standardization of strategies, elevated effectivity, doubtlessly diminished complication charges and new methods of integrating intra-operative imaging. Preclinical and medical proof is rising that helps the usage of autonomous robotic-assisted urological surgical procedure.

Podoplanin
MO47016 100 ul
EUR 349

Anti-Podoplanin Rabbit Monoclonal Antibody
M01124-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Podoplanin Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-Podoplanin Rabbit Monoclonal Antibody
M01124-2 100ug/vial
EUR 397
Description: Rabbit Monoclonal Podoplanin Antibody. Validated in WB and tested in Human.

Anti-Podoplanin/gp36/PDPN Antibody
PA1411 100ug/vial
EUR 294

Anti-Podoplanin/gp36/PDPN Antibody
PA1674 100ug/vial
EUR 294

Anti-Podoplanin/gp36/PDPN Antibody
PA1675 100ug/vial
EUR 294

Anti-Podoplanin/gp36/PDPN Antibody
A01124 100ug/vial
EUR 294

Anti-D2-40 Podoplanin antibody
STJ16100360 1 mL
EUR 1235

Anti-D2-40/Podoplanin antibody
STJ190048 200 µl
EUR 197
Description: Unconjugated Mouse monoclonal to D2-40/Podoplanin (7D1)

Mouse Podoplanin (PDPN) Protein
20-abx650139
  • EUR 648.00
  • EUR 272.00
  • EUR 1943.00
  • EUR 759.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Podoplanin ELISA kit
E03P0082-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Podoplanin ELISA kit
E03P0082-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Podoplanin ELISA kit
E03P0082-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Anti-Human Podoplanin monoclonal antibody, clone JID761
CABT-L2919-100uL500uL 100 uL, 500 uL
EUR 502

Podoplanin Antibody
P1051-01m 0.1m
EUR 209

Podoplanin Antibody
P1051-1ml 1ml
EUR 941

Podoplanin Antibody
49474-100ul 100ul
EUR 333

Podoplanin Antibody
49474-50ul 50ul
EUR 239

Podoplanin Antibody
DF12456 200ul
EUR 304
Description: Podoplanin antibody detects endogenous levels of Podoplanin.

Podoplanin antibody
10R-7662 100 ug
EUR 629
Description: Mouse monoclonal Podoplanin antibody

Podoplanin antibody
10R-7663 100 ug
EUR 629
Description: Hamster monoclonal Podoplanin antibody

Podoplanin antibody
10R-7664 100 ug
EUR 629
Description: Mouse monoclonal Podoplanin antibody

Podoplanin antibody
10R-P133a 100 ug
EUR 507
Description: Mouse monoclonal Podoplanin antibody

Podoplanin antibody
10R-P155a 100 ug
EUR 543
Description: Hamster monoclonal Podoplanin antibody

Podoplanin antibody
70R-6816 50 ug
EUR 467
Description: Rabbit polyclonal Podoplanin antibody raised against the N terminal of PDPN

Podoplanin antibody
70R-6817 50 ug
EUR 467
Description: Rabbit polyclonal Podoplanin antibody raised against the middle region of PDPN

Podoplanin antibody
70R-PR007 100 ug
EUR 422
Description: Affinity purified Rabbit polyclonal Podoplanin antibody

Podoplanin antibody
70R-11540 100 ug
EUR 527
Description: Rabbit polyclonal Podoplanin antibody

Podoplanin antibody
70R-13952 100 ug
EUR 305
Description: Affinity purified Rabbit polyclonal Podoplanin antibody

Podoplanin antibody
70R-50819 100 ul
EUR 244
Description: Purified Polyclonal Podoplanin antibody

Polyclonal Goat anti-GST α-form
GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 280

Mouse Podoplanin (PDPN) ELISA Kit
20-abx154564
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Podoplanin (PDPN) ELISA Kit
abx571749-96tests 96 tests
EUR 786

Mouse Podoplanin (PDPN) CLIA Kit
20-abx493858
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Podoplanin (PDPN) ELISA Kit
RDR-PDPN-Mu-48Tests 48 Tests
EUR 557

Mouse Podoplanin (PDPN) ELISA Kit
RDR-PDPN-Mu-96Tests 96 Tests
EUR 774

Mouse Podoplanin (PDPN) ELISA Kit
RD-PDPN-Mu-48Tests 48 Tests
EUR 533

Mouse Podoplanin (PDPN) ELISA Kit
RD-PDPN-Mu-96Tests 96 Tests
EUR 740

Mouse Podoplanin (PDPN) ELISA Kit
DLR-PDPN-Mu-48T 48T
EUR 527
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
DLR-PDPN-Mu-96T 96T
EUR 688
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids.

Podoplanin (PDPN) Polyclonal Antibody (Mouse)
4-PAC719Mu01
  • EUR 251.00
  • EUR 2576.00
  • EUR 640.00
  • EUR 316.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN)

Mouse Podoplanin (PDPN) ELISA Kit
SEC719Mu-10x96wellstestplate 10x96-wells test plate
EUR 4862.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
SEC719Mu-1x48wellstestplate 1x48-wells test plate
EUR 488.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
SEC719Mu-1x96wellstestplate 1x96-wells test plate
EUR 654.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
SEC719Mu-5x96wellstestplate 5x96-wells test plate
EUR 2644.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
4-SEC719Mu
  • EUR 4913.00
  • EUR 2595.00
  • EUR 655.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Podoplanin(PDPN)ELISA kit
QY-E21215 96T
EUR 361

Mouse Podoplanin, Pdpn ELISA KIT
ELI-06723m 96 Tests
EUR 865

Recombinant Mouse Podoplanin (C-Fc)
CU73-10ug 10ug
EUR 131
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Podoplanin (C-Fc)
CU73-1mg 1mg
EUR 1674
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Podoplanin (C-Fc)
CU73-500ug 500ug
EUR 1166
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Podoplanin (C-Fc)
CU73-50ug 50ug
EUR 273
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Podoplanin (PDPN) Antibody
20-abx131102
  • EUR 439.00
  • EUR 133.00
  • EUR 1233.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Podoplanin (PDPN) Antibody
20-abx129101
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Podoplanin (PDPN) Antibody
20-abx137407
  • EUR 704.00
  • EUR 328.00
  • EUR 230.00
  • 100 ug
  • 20 ug
  • 5 ug

Podoplanin (PDPN) Antibody
20-abx114559
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Podoplanin (PDPN) Antibody
20-abx123399
  • EUR 592.00
  • EUR 857.00
  • EUR 411.00
  • 100 ul
  • 200 ul
  • 50 ul

Podoplanin Blocking Peptide
20-abx063694
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Podoplanin (PDPN) Antibody
20-abx008317
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Podoplanin (PDPN) Antibody
20-abx005408
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Recombinant Human Podoplanin
7-05839 5µg Ask for price

Recombinant Human Podoplanin
7-05840 25µg Ask for price

Recombinant Human Podoplanin
7-05841 1mg Ask for price

Podoplanin (PDPN) Antibody
abx433110-200ul 200 ul
EUR 384

Podoplanin (PDPN) Protein
20-abx262003
  • EUR 4490.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 25 ug
  • 5 ug

Podoplanin (PDPN) Antibody
20-abx339428
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Podoplanin (PDPN) Antibody
abx236598-100ug 100 ug
EUR 551

Podoplanin (PDPN) Antibody
abx236599-100ug 100 ug
EUR 551

Podoplanin (PDPN) Antibody
20-abx178065
  • EUR 1233.00
  • EUR 592.00
  • 1 mg
  • 200 ug

Podoplanin (PDPN) Antibody
20-abx178066
  • EUR 1302.00
  • EUR 620.00
  • 1 mg
  • 200 ug

Podoplanin (PDPN) Antibody
20-abx178067
  • EUR 1414.00
  • EUR 662.00
  • 1 mg
  • 200 ug

Podoplanin (PDPN) Antibody
20-abx174125
  • EUR 857.00
  • EUR 439.00
  • 1 mg
  • 200 ug

Podoplanin (PDPN) Antibody
20-abx174126
  • EUR 913.00
  • EUR 467.00
  • 1 mg
  • 200 ug

Podoplanin (PDPN) Antibody
20-abx211099
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Podoplanin Conjugated Antibody
C49474 100ul
EUR 397

Recombinant Podoplanin (PDPN)
4-RPC719Hu01
  • EUR 413.60
  • EUR 214.00
  • EUR 1276.00
  • EUR 492.00
  • EUR 884.00
  • EUR 340.00
  • EUR 3040.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Podoplanin expressed in: E.coli

Recombinant Podoplanin (PDPN)
4-RPC719Mu01
  • EUR 458.40
  • EUR 226.00
  • EUR 1444.00
  • EUR 548.00
  • EUR 996.00
  • EUR 370.00
  • EUR 3460.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Podoplanin expressed in: E.coli

Podoplanin Blocking Peptide
DF12456-BP 1mg
EUR 195

Podoplanin Blocking Peptide
33R-9441 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PDPN antibody, catalog no. 70R-6817

Podoplanin Blocking Peptide
33R-2420 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PDPN antibody, catalog no. 70R-6816

Podoplanin Recombinant Protein
91-478 0.05 mg
EUR 448.25
Description: Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weakly expressed in brain, kidney and liver. In placenta, PDPN expressed on the apical plasma membrane of endothelium, in lung, expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, and major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. It requires for normal lung cell proliferation and alveolus formation at birth and Induces platelet aggregation. Nevertheless, it doesn’t have any effect on amino acid transport and the aquaporin-type water channels.

Podoplanin Recombinant Protein
91-788 0.05 mg
EUR 490.25
Description: Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weakly expressed in brain, kidney and liver. In placenta, PDPN expressed on the apical plasma membrane of endothelium, in lung, expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, and major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. It requires for normal lung cell proliferation and alveolus formation at birth and Induces platelet aggregation. Nevertheless, it doesn’t have any effect on amino acid transport and the aquaporin-type water channels.

Syrian Hamster Anti-Mouse Podoplanin (gp38) Monoclonal antibody, clone 8.1.1
CABT-L4294-1mg 1 mg
EUR 897

Syrian Hamster Anti-Mouse Podoplanin (gp38) Monoclonal antibody, clone 8.1.1
CABT-L4294-5mg 5 mg
EUR 2405

ELISA kit for Mouse PDPN (Podoplanin)
E-EL-M2409 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Mouse PDPN (Podoplanin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse Podoplanin (PDPN)
KTE70775-48T 48T
EUR 332
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Podoplanin (PDPN)
KTE70775-5platesof96wells 5 plates of 96 wells
EUR 2115
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Podoplanin (PDPN)
KTE70775-96T 96T
EUR 539
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse PDPN (Podoplanin)
ELK7080 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Podoplanin from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), APC
4-PAC719Mu01-APC
  • EUR 351.00
  • EUR 3365.00
  • EUR 935.00
  • EUR 449.00
  • EUR 222.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with APC.
Use of autonomous applied sciences within the working theatre will instantly have an effect on the position of the urological surgeon. Integration of autonomous RAS could be seen as a constructive help, however it may also be perceived as a risk to the longer term urological surgeon.